Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl triflate → 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl triflate | HCID 9526 | — |
| 반응물 | 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 69273758 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(2-Methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt | HCID 86595527 | — |
반응 단계
A solution of 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (1.4 g, 4.24 mmol) in methylene chloride was cooled in an ice bath, and trifluoromethanesulfonic acid methyl ester (0.56 mL, 4.9 mmol) was added via a pipet. After stirring at ice temperature for 3 h, the solvent was evaporated to give 4-(2-methyl-imidazole-1-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester triflate salt as yellow solids.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425638B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-38fad87017304b2ea8cf82845de81665 |
| 출처 메모 | uspto-grants-2008_09 |