Water → HCID 59792850, 화합물

HRID 31554노트

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HRID 31554 반응식
[Si]([O:8][CH2:9][C@@H:10]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31](=[O:39])[C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)=[CH:19][CH:18]=1)[C:11]([O:13][CH3:14])=[O:12])(C(C)(C)C)(C)C.O>C1COCC1>[OH:8][CH2:9][C@@H:10]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31](=[O:39])[C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)=[CH:19][CH:18]=1)[C:11]([O:13][CH3:14])=[O:12]

참가 물질

4

반응물 2

HCID 962WaterHCID 59792879Methyl (2r)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-{(1e)-3-[2-(4-methylbenzoyl)-1h-pyrrol-1-yl]prop-1-en-1-yl}benzyl)oxy]propionate

생성물 1

HCID 59792850HCID 59792850, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The compound of Example 68-4 (260 mg, 0.48 mmol) was dissolved in THF (5 ml), and thereto was added n-tetrabutylammonium fluoride (1 mol/liter in THF) (1.5 ml, 0.72 mmol) under ice-cooling. Under ice-cooling, the mixture was stirred for one hour, and thereto was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated saline, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound.

후처리

  1. temperaturecooling
  2. temperatureUnder ice-cooling
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water and saturated saline
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3c346d18f4f5487bbe9a2d98913b04a4
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425642B2

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