6,10-Dioxaspiro[4.5]dec-8-ylmethanol → 2-(((4-(6,10-Dioxaspiro[4.5]dec-8-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31627

반응식

HRID 31627 반응식
[Na:1].CO[CH:4]1[O:9][CH2:8][CH:7]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])[CH2:6][O:5]1.[CH2:31]1[C:35]2(OCC(CO)CO2)C[CH2:33][CH2:32]1>>[Na:1].[CH2:35]1[C:4]2([O:9][CH2:8][CH:7]([CH2:10][O:11][C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]4[NH:25][C:24]5[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=5[N:22]=4)=[O:20])[C:13]=3[CH3:30])[CH2:6][O:5]2)[CH2:33][CH2:32][CH2:31]1

참가 물질

3

반응물 2

HCID 597925846,10-Dioxaspiro[4.5]dec-8-ylmethanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

생성물 1

HCID 667766702-(((4-(6,10-Dioxaspiro[4.5]dec-8-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt수율 8.1%

실험 절차

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 6,10-dioxaspiro[4.5]dec-8-ylmethanol obtained in the step (21a) to obtain the title compound (180 mg, total yield: 8.1%) as a light yellow solid.

후처리

  1. customobtained in the step (21a)

출처 및 근거

ORD 기록
ord-69e9f342a8d54b43b43073174b0fdc7e
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425634B2

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