2-(2-Methyl-1,3-dioxan-2-yl)ethanol → 2-(((3-Methyl-4-(2-(2-methyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31640노트

반응식

HRID 31640 반응식
[Na:1].[CH3:2][C:3]1[C:4]([CH2:21][S:22]([C:24]2[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[N:25]=2)=[O:23])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][C:12]1([CH2:18]CC)[O:17][CH2:16][CH2:15][CH2:14][O:13]1.CC1(CCO)OCCCO1>>[Na:1].[CH3:2][C:3]1[C:4]([CH2:21][S:22]([C:24]2[NH:25][C:26]3[CH:32]=[CH:31][CH:30]=[CH:29][C:27]=3[N:28]=2)=[O:23])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][C:12]1([CH3:18])[O:17][CH2:16][CH2:15][CH2:14][O:13]1

참가 물질

3

반응물 2

HCID 596567682-(2-Methyl-1,3-dioxan-2-yl)ethanolHCID 667766942-(((3-Methyl-4-(2-(2-propyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

생성물 1

HCID 667764232-(((3-Methyl-4-(2-(2-methyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt수율 2.5%

실험 절차

The same procedure as in the steps (8c) to (8g) of Example 8, was repeated using 2-(2-methyl-1,3-dioxan-2-yl)ethanol obtained in the step (30a) to obtain the title compound (113 mg, total yield: 2.5%) as a light yellow solid.

후처리

  1. customobtained in the step (30a)

출처 및 근거

ORD 기록
ord-8f4ec6838a1448b2a391db087eab3312
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425634B2

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