(1,3-Dioxan-2-yl)methanol → 2-(((4-(1,3-Dioxan-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31642

반응식

HRID 31642 반응식
[Na:1].COC1OCC([CH2:10][O:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]3[NH:25][C:24]4[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=4[N:22]=3)=[O:20])[C:13]=2[CH3:30])CO1.[O:31]1[CH2:36][CH2:35][CH2:34][O:33][CH:32]1CO>>[Na:1].[O:31]1[CH2:36][CH2:35][CH2:34][O:33][CH:32]1[CH2:10][O:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]([CH2:18][S:19]([C:21]2[NH:22][C:23]3[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=3[N:25]=2)=[O:20])[C:13]=1[CH3:30]

참가 물질

3

반응물 2

HCID 142350(1,3-Dioxan-2-yl)methanolHCID 667760022-(((4-((2-Methoxy-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

생성물 1

HCID 667756932-(((4-(1,3-Dioxan-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt수율 10%

실험 절차

The same procedure as in the steps (6b) to (6f) of Example 6 was repeated using 1,3-dioxan-2-ylmethanol obtained in the step (32b) to obtain the title compound (148 mg, total yield:10%) as a light yellow solid.

후처리

  1. customobtained in the step (32b)

출처 및 근거

ORD 기록
ord-2a52fd0f87ad470eb3ab0841df3fd71f
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425634B2

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