Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Solketal → HCID 178431368, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Solketal | HCID 7528 | — |
| 반응물 | 4-Chloro-2,3-dimethyl-1-oxidopyridin-1-ium | HCID 9877446 | — |
| 반응물 | 2-(((4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775847 | — |
| 반응물 | HCID 178505474 | HCID 178505474 | — |
| 생성물 | HCID 178431368 | HCID 178431368 | 14.1% |
반응 단계
The same procedure as in the step (10b) of Example 10 and the step (14b) of Example 14, the step (5f) of Example 5, the steps (11h) and (11i) of Example 11 was repeated using solketal, 4-chloro-2,3-dimethylpyridine 1-oxide, and 5-fluoro-1H-benzimidazole-2-thiol to obtain the title compound (210 mg, yield: 14.1%) as a white solid. Note that methanol was used as a solvent instead of ethanol in the same operation as in the step (5f).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425634B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-a11e91989b544cc486de35037d86b48b |
| 출처 메모 | uspto-grants-2008_09 |