Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 31820생성일: 2026년 10월 26일
Dimethylformamide → [4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine
https://huagongshe.com/reaction/31820
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 6-Chloro-2-methoxy-3-nitropyridine | HCID 10797703 | — |
| 반응물 | 4-(2,4-Dichlorophenyl)-5-imidazolylpyrimidin-2-ylethylamine | HCID 54231773 | — |
| 생성물 | [4-(2,4-Dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl)) amino]ethyl}amine | HCID 22142635 | — |
반응 단계
To a solution of [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-ylethylamine (20 mg, 0.04 mmol) in DMF (1 ml), 2-methoxy-3-nitro-6-chloro-pyridine (8.3 mg, 0.04 mmol) and diisopropylethyl amine (31 μl, 0.18 mmol) were added. The reaction mixture was stirred for 12 hours at 80° C. The crude mixture was concentrated in vacuo and subjected to column chromatography (10% methanol in methylene chloride) to afford [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(6-methoxy-5-nitro(2-pyridyl))-amino]ethyl}amine as bright yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07425557B2 |
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| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-351c0e8e60d64b93b02b64e94b9240be |
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| 출처 메모 | uspto-grants-2008_09 |
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