Dimethylamine → 6-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14](SC)[N:15]=[CH:16][C:11]=2[CH:10]=1.[CH3:23][NH:24][CH3:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14]([N:24]([CH3:25])[CH3:23])[N:15]=[CH:16][C:11]=2[CH:10]=1

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 107367016-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

생성물 1

HCID 53278756-(2,6-dichlorophenyl)-2-(dimethylamino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one

실험 절차

This compound was prepared by a procedure similar to that described in Example 40 starting with 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one of Example 37 and dimethylamine gas; mp 256°-258° C.

후처리

customThis compound was prepared by a procedure similar to

출처 및 근거

ORD 기록: ord-3649f27493174d968301ce7cf9e817e4
출처 데이터셋: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05733914

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