2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-methoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

반응식

[Br:1][c:2]1[n:3][c:4]([CH2:8][CH2:9][O:10][CH3:11])[cH:5][cH:6][cH:7]1.[NH2:12][c:13]1[s:14][c:15](-[c:21]2[c:22]([F:32])[cH:23][c:24]([C:28]([CH3:29])([CH3:30])[OH:31])[cH:25][c:26]2[F:27])[cH:16][c:17]1[C:18](=[O:19])[NH2:20]>>[c:2]1([NH:12][c:13]2[s:14][c:15](-[c:21]3[c:22]([F:32])[cH:23][c:24]([C:28]([CH3:29])([CH3:30])[OH:31])[cH:25][c:26]3[F:27])[cH:16][c:17]2[C:18](=[O:19])[NH2:20])[n:3][c:4]([CH2:8][CH2:9][O:10][CH3:11])[cH:5][cH:6][cH:7]1

참가 물질

반응물 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HCID 595262782-Bromo-6-(2-methoxyethyl)pyridine

생성물 1

HCID 595262635-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-methoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide

출처 및 근거

ORD 기록: ord-b466fc9de68d4be5bab2c6b1c091e311
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

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