Dichloromethane → N-(3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-phenyl-2-thioxoimidazolidine-1-carboxamide

반응식

[Cl:59][CH2:60][Cl:61].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7].[F:8][c:9]1[c:10]([O:11][c:12]2[c:13]3[c:14]([n:15][cH:16][cH:17]2)[cH:18][c:19](-[c:21]2[cH:22][cH:23][c:24]([CH2:27][N:28]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:36][CH2:37][O:38][CH3:39])[cH:25][n:26]2)[s:20]3)[cH:40][cH:41][c:42]([NH:44][C:45](=[O:46])[N:47]2[C:48](=[S:58])[N:49]([c:52]3[cH:53][cH:54][cH:55][cH:56][cH:57]3)[CH2:50][CH2:51]2)[cH:43]1>>[F:8][c:9]1[c:10]([O:11][c:12]2[c:13]3[c:14]([n:15][cH:16][cH:17]2)[cH:18][c:19](-[c:21]2[cH:22][cH:23][c:24]([CH2:27][NH:28][CH2:36][CH2:37][O:38][CH3:39])[cH:25][n:26]2)[s:20]3)[cH:40][cH:41][c:42]([NH:44][C:45](=[O:46])[N:47]2[C:48](=[S:58])[N:49]([c:52]3[cH:53][cH:54][cH:55][cH:56][cH:57]3)[CH2:50][CH2:51]2)[cH:43]1