1-(2-Bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile → 4-Fluoro-1-[2-[[4-(hydroxymethyl)-1-bicyclo[2.2.2]octanyl]amino]acetyl]pyrrolidine-2-carbonitrile

반응식

[Br:12][CH2:13][C:14](=[O:15])[N:16]1[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]1.[NH2:1][C:2]12[CH2:3][CH2:4][C:5]([CH2:10][OH:11])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2>>[NH:1]([C:2]12[CH2:3][CH2:4][C:5]([CH2:10][OH:11])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2)[CH2:13][C:14](=[O:15])[N:16]1[CH:17]([C:22]#[N:23])[CH2:18][CH:19]([F:21])[CH2:20]1

참가 물질

반응물 2

HCID 231496951-(2-Bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile

HCID 23152950{4-Aminobicyclo[2.2.2]octan-1-yl}methanol

생성물 1

HCID 231529484-Fluoro-1-[2-[[4-(hydroxymethyl)-1-bicyclo[2.2.2]octanyl]amino]acetyl]pyrrolidine-2-carbonitrile

출처 및 근거

ORD 기록: ord-885361c5274c4873840205b3af3b1656
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

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