4-(Trifluoromethyl)benzoyl chloride → {5-Imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}(2-{[5-(trifluoro-methyl)(2-pyridyl)]amino}ethyl)amine
반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=O)=[CH:5][CH:4]=1.Cl[C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][N:16]=1.ClC1C=C(Cl)C=CC=1C1[C:38]([C:39]2[NH:40][CH:41]=[CH:42][N:43]=2)=[CH:37][N:36]=[C:35]([NH:44][CH2:45][CH2:46][NH:47]C2C=CC([N+]([O-])=O)=CN=2)[N:34]=1>>[NH:40]1[CH:41]=[CH:42][N:43]=[C:39]1[C:38]1[C:7]([C:6]2[CH:10]=[CH:11][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)=[N:34][C:35]([NH:44][CH2:45][CH2:46][NH:47][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][N:16]=2)=[N:36][CH:37]=1참가 물질
4
실험 절차
{5-imidazol-2-yl-4-[4-(trifluoromethyl)phenyl]pyrimidin-2-yl}(2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine was prepared from 4-(trifluoromethyl)benzoyl chloride and 2-chloro-5-(trifluoromethyl)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine