1,2-Dimethylimidazole → [4-(2,4-Dichlorophenyl)-5-(1-methylimidazol-2-yl)pyrimidin-2-yl](2-{[5-(trifluoro-methyl)(2-pyridyl)]amino}ethyl)amine

HRID 31879

반응식

HRID 31879 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH3:7].Cl[C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:10]=1.[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=1[C:27]1C(C2NC=CN=2)=[CH:31][N:30]=[C:29]([NH:38][CH2:39][CH2:40][NH:41]C2C=CC([N+]([O-])=O)=CN=2)[N:28]=1>>[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[CH:22][C:21]=1[C:27]1[C:7]([C:3]2[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=2)=[CH:31][N:30]=[C:29]([NH:38][CH2:39][CH2:40][NH:41][C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][N:10]=2)[N:28]=1

참가 물질

4

반응물 3

HCID 156171,2-DimethylimidazoleHCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 9847557Chir-98023

생성물 1

HCID 22142893[4-(2,4-Dichlorophenyl)-5-(1-methylimidazol-2-yl)pyrimidin-2-yl](2-{[5-(trifluoro-methyl)(2-pyridyl)]amino}ethyl)amine

실험 절차

[4-(2,4-dichlorophenyl)-5-(1-methylimidazol-2-yl)pyrimidin-2-yl](2-{[5-(trifluoromethyl)(2-pyridyl)]amino}ethyl)amine was prepared from 1,2-dimethylimidazole and 2-chloro-5-(trifluoromethyl)pyridine using the general method for [4-(2,4-dichlorophenyl)-5-imidazol-2-ylpyrimidin-2-yl]{2-[(5-nitro(2-pyridyl))amino]ethyl}amine.

출처 및 근거

ORD 기록
ord-42cbda824ce34d87ade1971b45f0036f
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425557B2

연결된 노트

불러오는 중…