1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine → 6-(2,6-Dichlorophenyl]-2-[3-[4-(2-methoxyphenyl)-piperazin-1-yl]-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

HRID 3192노트

반응식

HRID 3192 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14](SC)[N:15]=[CH:16][C:11]=2[CH:10]=1.[NH2:23][CH2:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=2[O:39][CH3:40])[CH2:29][CH2:28]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[C:20](=[O:21])[N:19]([CH3:22])[C:12]2[N:13]=[C:14]([NH:23][CH2:24][CH2:25][CH2:26][N:27]3[CH2:32][CH2:31][N:30]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=4[O:39][CH3:40])[CH2:29][CH2:28]3)[N:15]=[CH:16][C:11]=2[CH:10]=1

참가 물질

3

반응물 2

HCID 104672591-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazineHCID 107367016-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

생성물 1

HCID 116784236-(2,6-Dichlorophenyl]-2-[3-[4-(2-methoxyphenyl)-piperazin-1-yl]-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

실험 절차

This compound was prepared by a procedure similar to that described in Example 49 starting with 0.165 g (0.47 mmol) of 6-(2,6-dichlorophenyl)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one of Example 37 and 1.00 g (4.00 mmol) of 1-(3-aminopropyl)-4-(2-methoxyphenyl)piperazine yielding 0.103 g of pure product; mp 187°-188° C.

후처리

  1. customThis compound was prepared by a procedure similar to

출처 및 근거

ORD 기록
ord-16b1b5b57c634a8aa4a0c762c66831e2
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733914

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