Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → Tert-butyl(chroman-4-yloxy)dimethylsilane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | Chroman-4-ol | HCID 92890 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Tert-butyl(chroman-4-yloxy)dimethylsilane | HCID 18448670 | — |
반응 단계
tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425631B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-8fbaecf91b4346379115785c32c01434 |
| 출처 메모 | uspto-grants-2008_09 |