Trifluoroacetic acid → Trifluoroacetic acid

HRID 32082노트

반응식

HRID 32082 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:14]=2)[CH2:9]1)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[N:19]1([CH2:18][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][CH:8]([NH2:7])[CH2:17][CH2:16]3)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 59486432HCID 59486432, 화합물

생성물 2

HCID 6422Trifluoroacetic acidHCID 59486397HCID 59486397, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(6-Piperidin-1-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester (Step E) (0.113 g, 0.327 mmol) was suspended in CH2Cl2 (2.5 mL) then TFA was added (2.5 mL). The reaction was stirred at RT until complete consumption of starting material was observed by HPLC analysis (2 h). The reaction mixture was concentrated in vacuo to afford the crude title compound as the bis-TFA salt, which was used without further purification. MS (APCI pos) 245 (M+H).

후처리

  1. customwas observed by HPLC analysis (2 h)
  2. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-86d1c68262054a1786359a55d7cc21fa
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425631B2

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