Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione → 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione | HCID 359353 | — |
| 반응물 | 3-(Tert-butyldiphenylsilyloxy)propanamidine | HCID 58841407 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 58841347 | — |
반응 단계
A solution of 3-(tert-butyl-diphenyl-silanyloxy)-propionamidine (25 g, 77 mmol) and 2-dimethylaminomethylene-cyclohexane-1,3-dione (12.8 g, 77 mmol) in 400 mL of dry EtOH was heated at 80° C. for 3 h. After cooling to RT, the solvent was evaporated. Flash chromatography (SiO2, EtOAc/hexane=1:1) gave the desired compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07425631B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-1934d873284f448895a79663ca6cef26 |
| 출처 메모 | uspto-grants-2008_09 |