Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 32165생성일: 2026년 10월 24일
2-Chloroethyl methyl sulfide → 1-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
https://huagongshe.com/ko/reaction/32165
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Chloroethyl methyl sulfide | HCID 10965 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-[2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]piperazine | HCID 11992284 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(2-Methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine | HCID 23142785 | 70.5% |
반응 단계
A mixture of the 1-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine (100 mg, 0.333 mmol) produced in Example (8b), 2-chloroethyl methyl sulfide (38.7 mg, 0.349 mmol), potassium carbonate (78.2 mg, 0.566 mmol) and acetonitrile (2 mL) was stirred for 8 hours and 30 minutes at an external temperature of 80° C. The reaction mixture was concentrated and the resultant residue was purified by NH silica gel column chromatography (ethyl acetate/heptane) to give 88 mg of 1-(2-methylsulfanylethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07425554B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
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| ORD ID | ord-bd9582084aa347fba5c296a15048dd4a |
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| 출처 메모 | uspto-grants-2008_09 |
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