Glyoxal, phenyl-, hydrate → 2-(3,5-Dichlorophenyl)-5-phenyl-2,3-dihydro-1,2,4-triazin-3-one

HRID 321980

반응식

HRID 321980 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]([C:11]([NH2:13])=[O:12])[NH2:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.O.[C:15]1([C:21]([CH:23]=O)=O)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:11](=[O:12])[N:13]=[C:21]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:23]=[N:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 12215922Glyoxal, phenyl-, hydrateHCID 155216502-(3,5-Dichlorophenyl)semicarbazide

생성물 1

HCID 155216512-(3,5-Dichlorophenyl)-5-phenyl-2,3-dihydro-1,2,4-triazin-3-one수율 42.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

In 50 ml of dioxane was dissolved 2.20 g of 2-(3,5-dichlorophenyl)semicarbazide followed by addition of 1.52 g of phenylglyoxal monohydrate, and the mixture was refluxed for 5 hours. The reaction mixture was then concentrated and the residue was recrystallized from acetonitrile to provide 1.34 g of the title compound. m.p. 160-161° C.

후처리

  1. temperaturethe mixture was refluxed for 5 hours
  2. concentrationThe reaction mixture was then concentrated
  3. customthe residue was recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-97d8a8a988414f908a826ffd10fbc537
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211178B1

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