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Benzaldehyde → Benzaldehyde 4-(4-chloro-alpha-cyanobenzyl)-3,5-dichlorophenyl hydrazone

HRID 321987
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HRID 321987 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH:6]([C:9]2[C:14]([Cl:15])=[CH:13][C:12]([NH:16][NH2:17])=[CH:11][C:10]=2[Cl:18])[C:7]#[N:8])=[CH:4][CH:3]=1.[CH:21](=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.S([O-])([O-])(=O)=O.[Mg+2]>C(OC(=O)C)C>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH:6]([C:9]2[C:10]([Cl:18])=[CH:11][C:12]([NH:16][N:17]=[CH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:13][C:14]=2[Cl:15])[C:7]#[N:8])=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 220085374-(4-Chloro-alpha-cyanobenzyl)-3,5-dichlorophenyl hydrazine

생성물 1

HCID 86754869Benzaldehyde 4-(4-chloro-alpha-cyanobenzyl)-3,5-dichlorophenyl hydrazone

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

In 30 ml of acetic acid ethyl ester was dissolved 3.26 g of 4-(4-chloro-α-cyanobenzyl)-3,5-dichlorophenyl hydrazine. To the solution was added equimolar benzaldehyde and three times as much mol. of anhydrous magnesium sulfate, then the reaction was allowed to proceed for one hour at room temperature. After completion of the reaction, insolubles were removed, and the solution was concentrated, which was recrystallized from acetonitrile to afford 3.3 g of the titled compound as colorless crystals, m.p.162-163° C.

후처리

  1. customAfter completion of the reaction, insolubles
  2. customwere removed
  3. concentrationthe solution was concentrated
  4. customwhich was recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-1498695bf0a84033b1a6147d20c71936
출처 데이터셋
uspto-grants-2001_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06211178B1

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