Acetyl chloride → (S)-(+)-2-Phenylglycine methyl ester hydrochloride

HRID 322050

반응식

HRID 322050 반응식
[C:1]([Cl:4])(=O)C.[CH:5]1[CH:10]=[CH:9][C:8]([C@@H:11]([NH2:15])[C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1>CO>[CH3:1][O:13][C:12]([C@@H:11]([NH2:15])[C:8]1[CH:7]=[CH:6][CH:5]=[CH:10][CH:9]=1)=[O:14].[ClH:4]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 70134Phenylglycine, D-

생성물 1

HCID 11217910(S)-(+)-2-Phenylglycine methyl ester hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Acetyl chloride (4 ml) was added cautiously and dropwise to methanol (20 ml) at 0° C. over 2 minutes. When the addition was completed, D-phenylglycine (1 g, 5.9 mmol, Aldrich) was introduced in a single portion. The mixture was stirred until dissolved then allowed to stand at RT for 24 hours. The solvent was evaporated then coevaporated twice from toluene to afford the title compound as a white crystalline solid in quantitative yield. The title compound was obtained as a white crystalline solid in quantitative yield with an identical n.m.r. spectrum to the L-isomer.

후처리

  1. additionWhen the addition
  2. dissolutionuntil dissolved
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-92368913d9c2407190b644d8376d9a3c
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211212B1

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