Triethylamine → N-(3-bromopropyl)acetoacetamide

HRID 322130

반응식

HRID 322130 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.Br.[Br:8][CH2:9][CH2:10][CH2:11][NH2:12].C(N(CC)CC)C>C1COCC1>[Br:8][CH2:9][CH2:10][CH2:11][NH:12][C:4](=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12661DiketeneHCID 787013-Bromopropylamine hydrobromide

생성물 1

HCID 23004079N-(3-bromopropyl)acetoacetamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Diketene (1.22 mL, 15.7 mmol, 1.50 equiv) was added at room temperature to a stirred mixture of 3-bromopropylamine hydrobromide (2.30 g, 10.5 mmol, 1.00 equiv) and triethylamine (1.46 mL, 10.5 mmol, 1.00 equiv) in anhydrous THF (20 mL) under argon, and stirring was continued at room temperature for 1 hour. The solvent was removed and the residue was purified by flash chromatography (SiO2, MeOH—CH2Cl2 0:1 to 1:18) to afford a light yellow oil, 2.10 g (90%), which was characterized spectroscopically.

후처리

  1. customThe solvent was removed
  2. customthe residue was purified by flash chromatography (SiO2, MeOH—CH2Cl2 0:1 to 1:18)
  3. customto afford a light yellow oil, 2.10 g (90%), which

출처 및 근거

ORD 기록
ord-ab1d04208ba942d5ab38c7f9319c154c
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211198B1

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