1-[4-(4-Benzyloxyphenyl)butyl]-1,2,4-triazole → 1-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazole

HRID 322256노트

반응식

HRID 322256 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[C].[Pd].C(O)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)=[CH:11][CH:10]=1

참가 물질

4

반응물 1

HCID 220098341-[4-(4-Benzyloxyphenyl)butyl]-1,2,4-triazole

생성물 1

HCID 220096301-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazole수율 55%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

A mixture of 1-[4-(4-benzyloxyphenyl)butyl]-1,2,4-triazole (3.15 g), palladium-carbon (5%, 3.0 g) and ethanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated. The residue was subjected to a silica gel column chromatography. The crystalline product obtained from the fraction eluted with tetrahydrofuran-hexane (1:1, v/v) was recrystallized from ethyl acetate-hexane to give 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole (1.22 g, 55%) as colorless prisms, mp 135-136° C.

후처리

  1. customwas subjected to catalytic hydrogenation under atmospheric pressure at room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe crystalline product obtained from the fraction
  5. washeluted with tetrahydrofuran-hexane (1:1
  6. customv/v) was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-48e1fa762fb7461fb53c2c44b99a5ac7
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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