참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,3-Dichloroacetone | HCID 10793 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Propenamide, 3-phenyl- | HCID 12135 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloromethyl-2-styryl-oxazole | HCID 22009752 | 47% |
반응 단계
A mixture of cinnamamide (25.3 g) and 1,3-dichloroacetone (20.9 g) was stirred for one hour at 130° C. The reaction mixture was diluted with water, neutralized with potassium carbonate, and extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4), and concentrated under reduced pressure. The residue was subjected to a silica gel column chromatography. From the fraction eluted with diethyl ether-hexane, 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole (16.9 g, 47%) was obtained. Recrystallization from diethyl ether-hexane gave colorless needles, mp 72-73° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06211215B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_04 |
|---|
| ORD ID | ord-60507feac8c145038b96233133a1f837 |
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| 출처 메모 | uspto-grants-2001_04 |
|---|
