HCID 4065946, 화합물 → 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol

반응식

[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15](OCC)=[O:16])=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH2:1]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH2:13][CH2:14][CH2:15][OH:16])=[CH:11][C:10]=1[O:22][CH3:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 4065946HCID 4065946, 화합물

HCID 21226445Aluminium lithium hydride

생성물 1

HCID 145208533-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol수율 56%

실험 절차

In substantially the same manner as in Reference Example 82, ethyl 4-benzyloxy-3-methoxycinnamate was subjected to reduction with lithium aluminum hydride to obtain 3-(4-benzyloxy-3-methoxyphenyl)propanol. The yield was 56%. Recrystallization from ethyl acetate-hexane gave colorless prisms, 57-58° C.

출처 및 근거

ORD 기록: ord-63bf6bfc321c44ce81df430c711d3926
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

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