1H-1,2,4-Triazole → HCID 15521673, 화합물

반응식

[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25]O)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:27]1[CH:31]=[N:30][CH:29]=[N:28]1>>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][N:27]4[CH:31]=[N:30][CH:29]=[N:28]4)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 92571H-1,2,4-Triazole

HCID 10337891HCID 10337891, 화합물

생성물 1

HCID 15521673HCID 15521673, 화합물수율 71%

실험 절차

In substantially the same manner as in Working Example 1, 4-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]butanol was allowed to react with 1,2,4-triazole to give 1-[4-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole. The yield was 71%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 94-95° C.

출처 및 근거

ORD 기록: ord-ba8511d99dcb4a908a6229139d04b76c
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

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