Imidazole → HCID 22009692, 화합물

HRID 322351노트

반응식

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.CS(O[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]2[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[O:25][CH:26]=2)=[C:16]([O:35][CH3:36])[CH:15]=1)(=O)=O>>[N:1]1([CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]3[N:23]=[C:24](/[CH:27]=[CH:28]/[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=4)[O:25][CH:26]=3)=[C:16]([O:35][CH3:36])[CH:15]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

반응물 2

HCID 795Imidazole

HCID 22009860HCID 22009860, 화합물

생성물 1

HCID 22009692HCID 22009692, 화합물수율 60%

실험 절차

In substantially the same manner as in Working Example 8, imidazole was allowed to react with 3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate to give 4-[4-[3-(1-imidazolyl)propyl]-2-methoxyphenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 60%. Recrystallization from ethyl acetate-hexane gave colorless prisms, m,p.95-96° C.

출처 및 근거

ORD 기록: ord-6513ecb93b144c06b4be3298abef8e92
출처 데이터셋: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06211215B1

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