1-(p-Hydroxyphenyl)imidazole → 4-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole

HRID 322377

반응식

HRID 322377 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:4][CH:3]=1.Cl[CH2:14][C:15]1[N:16]=[C:17](/[CH:20]=[CH:21]/[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[O:18][CH:19]=1>>[N:8]1([C:5]2[CH:4]=[CH:3][C:2]([O:1][CH2:14][C:15]3[N:16]=[C:17](/[CH:20]=[CH:21]/[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[O:18][CH:19]=3)=[CH:7][CH:6]=2)[CH:12]=[CH:11][N:10]=[CH:9]1

참가 물질

3

반응물 2

HCID 823151-(p-Hydroxyphenyl)imidazoleHCID 220097524-Chloromethyl-2-styryl-oxazole

생성물 1

HCID 220098234-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole수율 68%

실험 절차

In substantially the same manner as in Working Example 37, 1-(4-hydroxyphenyl)imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole to give 4-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 68%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 160-162° C.

출처 및 근거

ORD 기록
ord-a2539587f2ab45ccb443b3bde9bdc63f
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

연결된 노트

불러오는 중…