4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazole → 4-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole

HRID 322402노트

반응식

HRID 322402 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[S:24][CH:25]=[CH:26][CH:27]=2)[O:21][CH:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[O:1][CH2:17][C:18]2[N:19]=[C:20]([C:23]3[S:24][CH:25]=[CH:26][CH:27]=3)[O:21][CH:22]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

참가 물질

3

반응물 2

HCID 25295314-(Chloromethyl)-2-(thiophen-2-yl)-1,3-oxazoleHCID 220098091-[3-(3-Hydroxyphenyl)propyl]imidazole

생성물 1

HCID 220098004-[3-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole수율 78%

실험 절차

In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(2-thienyl)oxazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(2-thienyl)oxazole, oily substance. The yield was 78%.

출처 및 근거

ORD 기록
ord-438c560d72d544f8aaa185dace7518f4
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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