2-(4-Benzoylphenyl)-4-chloromethyloxazole → 2-(4-Benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

HRID 322404

반응식

HRID 322404 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:5]=[CH:6][CH:7]=1.[C:16]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[O:31][CH:32]=[C:33]([CH2:35]Cl)[N:34]=2)=[CH:26][CH:25]=1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([C:24]1[CH:29]=[CH:28][C:27]([C:30]2[O:31][CH:32]=[C:33]([CH2:35][O:1][C:2]3[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)[CH:3]=3)[N:34]=2)=[CH:26][CH:25]=1)(=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 220098072-(4-Benzoylphenyl)-4-chloromethyloxazoleHCID 220098091-[3-(3-Hydroxyphenyl)propyl]imidazole

생성물 1

HCID 220097902-(4-Benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole수율 85%

실험 절차

In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(4-benzoylphenyl)-4-chloromethyloxazole to gave 2-(4-benzoylphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 85%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 97-98° C.

출처 및 근거

ORD 기록
ord-86f23639e16b4be89e1959184e9540ee
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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