Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[3-(3-Hydroxyphenyl)propyl]imidazole → 2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[3-(3-Hydroxyphenyl)propyl]imidazole | HCID 22009809 | — |
| 반응물 | 2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole | HCID 22009845 | — |
| 생성물 | 2-(4-Benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009625 | 81% |
반응 단계
In substantially the same manner as in Working Example 72, 1-[3-(3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(4-benzyloxyphenyl)-4-chloromethyloxazole to give 2-(4-benzyloxyphenyl)-4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 144-145° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211215B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-b40a9129cf504fcc8cbcba254d087a33 |
| 출처 메모 | uspto-grants-2001_04 |