4-(Chloromethyl)-2-phenyl-1,3-thiazole → HCID 22009596, 화합물

HRID 322414노트

반응식

HRID 322414 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[S:21][CH:22]=1>>[N:11]1([CH2:10][CH2:9][CH2:8][C:4]2[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=2)[O:1][CH2:17][C:18]2[N:19]=[C:20]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[S:21][CH:22]=2)[CH:15]=[CH:14][N:13]=[CH:12]1

참가 물질

3

반응물 2

HCID 2369694-(Chloromethyl)-2-phenyl-1,3-thiazoleHCID 220098091-[3-(3-Hydroxyphenyl)propyl]imidazole

생성물 1

HCID 22009596HCID 22009596, 화합물수율 81%

실험 절차

In substantially the same manner as in Working Example 72, 1-[3-(3-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-phenylthiazole to give 4-[3-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-phenylthiazole. The yield was 81%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 63-64° C.

출처 및 근거

ORD 기록
ord-a101a9a1a4ac440692d45f0865a967ea
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

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