Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[3-(4-Hydroxyphenyl)propyl]imidazole → 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| 반응물 | 4-Chloromethyl-2-(3-methyl-2-thienyl)oxazole | HCID 22009832 | — |
| 생성물 | 4-[4-[3-(1-Imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole | HCID 22009702 | 78% |
반응 단계
In substantially the same manner as in Working Example 72, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(3-methyl-2-thienyl)oxazole to give 4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-2-(3-methyl-2-thienyl)oxazole. The yield was 78%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 72-73° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211215B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-af21ce97a14c420686ff378c9c133ddc |
| 출처 메모 | uspto-grants-2001_04 |