Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine → 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 11622894 | — |
| 반응물 | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| 생성물 | 6-Bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine | HCID 22009851 | 57% |
반응 단계
In substantially the same manner as in Working Example 109, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 6-bromo-2-chloromethylimidazo[1,2-a]pyridine to give 6-bromo-2-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]imidazo[1,2-a]pyridine. The yield was 57%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 103-104° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211215B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-d7bb8b1d28d846d68bd82fd358c0148f |
| 출처 메모 | uspto-grants-2001_04 |