3-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone → (3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

HRID 322547노트

반응식

HRID 322547 반응식
COC1C=CC(C[NH:8][C:9]2[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=2)=CC=1>FC(F)(F)C(O)=O>[NH2:8][C:9]1[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=1

참가 물질

3

반응물 1

HCID 220087443-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone

생성물 1

HCID 22008747(3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The pyrazinone 18-6 (900 mg) was heated at reflux in trifluoroacetic acid (20 mL) for 7 h. The volatiles were removed in vacuo and the residue was azeotroped with CH2Cl2, then EtOAc then MeOH. MeOH was added to the residue and the solution filtered to remove impurities. Removal of the methanol then afforded the title compound 18-7 which was used as such:

후처리

  1. customThe volatiles were removed in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. additionMeOH was added to the residue
  4. filtrationthe solution filtered
  5. customto remove impurities
  6. customRemoval of the methanol

출처 및 근거

ORD 기록
ord-8b4d4be21f104dcea21508ba435f4df0
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211184B1

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