참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Harmaline | HCID 3564 | — |
| 반응물 | Coronaridine | HCID 73489 | — |
| 반응물 | (-)-Ibogamin | HCID 442109 | — |
| 반응물 | methyl (1S,17R,18S)-17-(2-methoxyethyl)-3,13-diazapentacyclo[13.3.1.02,10.04,9.013,18]nonadeca-2(10),4,6,8-tetraene-1-carboxylate | HCID 46877888 | — |
| 생성물 | 10-Methoxyibogamine | HCID 442108 | — |
반응 단계
Ibogamine (20-40 mg/kg), harmaline (10-40 mg/kg) and desethycoronaridine (10-40 mg/kg) were obviously tremorigenic for 3-4 h and no attempt was made to compare these drugs quantitatively. However, visual observations and videotape recordings of 18-methoxycoronaridine (40 mg/kg) and both R- and S-enantiomers of both ibogamine (40 mg/kg) and coronaridine (40 mg/kg) indicated very little if any tremorigenic activity. The effects of these latter drugs were therefore assessed using the automated testing procedure developed to quantitate tremors. Ibogains (40 mg/kg) and saline (1 ml/kg) were used as positive and negative controls, respectively. While ibogaine produced a significant increase in movements indicative of tremors, the 18-methoxycoronaridine and the ibogamine and coronaridine enantiomers had no effects that differed significantly from the effects of saline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06211360B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_04 |
|---|
| ORD ID | ord-c80861e958dc4fc5b0eeefc8b9b7a0ee |
|---|
| 출처 메모 | uspto-grants-2001_04 |
|---|
