Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Alanine ethyl ester → N-[(3,5difluorophenyl)acetyl]alanine Ethyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Alanine ethyl ester | HCID 76507 | — |
| 반응물 | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| 생성물 | N-[(3,5difluorophenyl)acetyl]alanine Ethyl Ester | HCID 54306296 | — |
반응 단계
Following General Procedure G′ and using 3,5-difluorophenylacetic acid (Aldrich) and alanine ethyl ester (Aldrich), the title compound was prepared as a solid with a melting point of 93°-95° C. The reaction was monitored by tlc on silica gel (Rf=0.8 in EtOAC) and purification was by chromatography on silica gel using EtOAc as the eluant followed by recrystallization from 1 -chlorobutane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211235B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-41d32c054b3a4a5990ecd323c882706c |
| 출처 메모 | uspto-grants-2001_04 |