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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 322722생성일: 2026년 10월 26일

(S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl Ester

https://huagongshe.com/reaction/322722

반응식

참여 물질

역할이름HCID투입량
반응물(S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoateHCID 7018776—
반응물(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 12135350—
생성물N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl EsterHCID 20642604—

반응 단계

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and Nε-(tert-butoxycarbonyl)-L-lysine methyl ester (Bachem), the title compound was prepared as an oil. The reaction was monitored by tlc (Rf=0.40 in 50% EtOAc/hexanes) and the product was purified by flash chromotography using 50% EtOAc/hexanes as the eluent.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06211235B1
출처 데이터셋uspto-grants-2001_04
ORD IDord-b8ac866f51894f699edcab131f6d81aa
출처 메모uspto-grants-2001_04