Triethylamine → N-(1-Cyanocyclopentyl)pentanamide

HRID 322810

반응식

HRID 322810 반응식
[NH2:1][C:2]1([C:7]#[N:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:16](Cl)(=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20]>ClCCl>[C:7]([C:2]1([NH:1][C:16](=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:6][CH2:5][CH2:4][CH2:3]1)#[N:8]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 21068971-Aminocyclopentanecarbonitrile

생성물 1

HCID 11790092N-(1-Cyanocyclopentyl)pentanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
32.5 °C

실험 절차

To 11.0 g (0.1 mol) of 1-amino-1-cyanocyclopentane dissolved in 100 ml of dichloromethane, 15 ml 10. g (0.1 mol) of triethylamine was added, then dropwise 13 ml, 13 g (0.1 mol) of valeroyl chloride, while keeping the temperature at 25-35° C. The reaction mixture was stirred at 30-35° C. for 2 hours, then it was washed with water. The phases were separated, the organic phase was evaporated to obtain the pure title compound as an oil. The compound was identified by elementary analysis, IR, NMR and GC-MS spectrometry.

후처리

  1. customat 25-35° C
  2. washit was washed with water
  3. customThe phases were separated
  4. customthe organic phase was evaporated

출처 및 근거

ORD 기록
ord-c955579b5894498eafbf043d733950c1
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211382B1

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