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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 322878생성일: 2026년 10월 26일

Benzyl 3-hydroxyphenyl ether → ethyl (RS)-4-[2-(N-ethylcarbamoyl)-5-benzyloxyphenoxy]-4-phenyl-butanoate

https://huagongshe.com/reaction/322878

반응식

참여 물질

역할이름HCID투입량
반응물Benzyl 3-hydroxyphenyl etherHCID 138048—
반응물3-(3-Thienylmethoxy)phenolHCID 10726965—
반응물Ethyl 4-chloro-4-phenylbutanoateHCID 12847348—
반응물2-hydroxy-4-benzyloxy-N-ethylbenzamideHCID 22010411—
반응물4-PhenylbutyrateHCID 22053264—
반응물ethyl (RS)-4-[3-(3-thienylmethoxy)phenoxy]-4-phenylbutanoateHCID 23204074—
생성물ethyl (RS)-4-[2-(N-ethylcarbamoyl)-5-benzyloxyphenoxy]-4-phenyl-butanoateHCID 23204260—

반응 단계

By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 3-benzyloxyphenol and ethyl (RS)-4-chloro-4-phenylbutanoate with ethyl (RS)-4-chloro-4-(2-methyl)phenylbutanoate, there is prepared ethyl (RS)-4-[(3-benzyloxy)phenoxy]-4-(2-methylphenyl)butanoate. By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 3-(3-thienylmethoxy)phenol, there is prepared ethyl (RS)-4-[3-(3-thienylmethoxy)phenoxy]-4-phenylbutanoate. By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 2-hydroxy-4-(3-thienylmethoxy)acetophenone, there is prepared ethyl (RS)-4-[2-acetyl-5-(3-thienylmethoxy)phenoxy)]-4-phenylbutanoate. By proceeding in a similar manner but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 2-hydroxy-4-benzyloxy-N-ethylbenzamide there is obtained ethyl (RS)-4-[2-(N-ethylcarbamoyl)-5-benzyloxyphenoxy]-4-phenyl-butanoate. By proceeding in a similar manner but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 2-hydroxy-4-(3-thienylmethoxy)acetophenone and ethyl (RS)-4-chloro-4-phenylbutanoate with ethyl (RS)-4-chloro-4-(2-methylphenyl)butanoate, there is prepared ethyl (RS)-4-[2-acetyl-5-(3-thienylmethoxy)phenoxy]-4-(2-methylphenyl)-butanoate. By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 2-hydroxy-4-(3-pyridylmethoxy)acetophenone, there is prepared ethyl (RS)-4-[2-acetyl-5-(3-pyridylmethoxy)phenoxy]-4-phenylbutanoate. By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 4-benzyloxy-2-hydroxybenzamide, there is prepared ethyl (RS)-4-[2-carbamoyl-5-benzyloxyphenoxy]-4-phenylbutanoate. By proceeding in a similar manner, but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 4-benzyloxy-2-hydroxy-N,N-dimethylbenzamide, there is prepared ethyl (RS)-4-[2-N,N-dimethylcarbamoyl-5-benzyloxyphenoxy]-4-phenylbutanoate. By proceeding in a similar manner. but replacing methyl 4-benzyloxy-2-hydroxybenzoate with 4-(3-thienylmethoxy)-2-hydroxybenzamide and ethyl (RS)-4-chloro-4-phenylbutanoate with ethyl (RS)-4-chloro-4-(2-methylphenyl)butanoate, there is prepared ethyl (RS)-4-[2-carbamoyl-5-(3-thienylmethoxy)phenoxy]-4-(2-methylphenyl)butanoate.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06211234B1
출처 데이터셋uspto-grants-2001_04
ORD IDord-0f72d0e1a8c94f408f6bd9fb7d54180f
출처 메모uspto-grants-2001_04