참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4'-Benzyloxy-2'-hydroxyacetophenone | HCID 309257 | — |
| 반응물 | Ethyl 4-chloro-4-phenylbutanoate | HCID 12847348 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | ethyl (RS)-4-(2-acetyl-5-benzyloxy-phenoxy)-4-phenylbutanoate | HCID 23204307 | 34.1% |
반응 단계
A mixture of 4-benzyloxy-2-hydroxyaceto-phenone (1.2 g), ethyl (RS)-4-chloro-4-phenyl-butanoate (1.21 g), potassium carbonate (760 mg), potassium iodide (35 mg) and dimethylformamide (30 mL) is stirred at 100° C. for 8 hours. It is evaporated to dryness and the resulting residue is partitioned between ethyl acetate (200 mL) and water (200 mL). The organic layer is dried over magnesium sulphate, filtered and concentrated in vacuo. Flash chromatography of the resulting oil, eluting with 15-30% ethyl acetate/hexane, affords ethyl (RS)-4-(2-acetyl-5-benzyloxy-phenoxy)-4-phenylbutanoate (0.73 g), in the form of a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06211234B1 |
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| 출처 데이터셋 | uspto-grants-2001_04 |
|---|
| ORD ID | ord-38a7180b845244e4becca23853d94f6e |
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| 출처 메모 | uspto-grants-2001_04 |
|---|
