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Water → 2-[2,2-Dimethyl-6-(4-Fluorophenyl)morpholin-4-yl]-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one

HRID 32304
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HRID 32304 반응식
Cl.[CH3:2][C:3]1([CH3:16])[O:8][CH:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:6][NH:5][CH2:4]1.Cl[C:18]1[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)[N:19]=1.C(N(CC)CC)C.O>CN(C)C=O>[CH3:2][C:3]1([CH3:16])[O:8][CH:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH2:6][N:5]([C:18]2[N:23]([CH3:24])[C:22](=[O:25])[CH:21]=[C:20]([C:26]3[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=3)[N:19]=2)[CH2:4]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 112760814(3H)-Pyrimidinone, 2-chloro-3-methyl-6-(4-pyridinyl)-HCID 688833732,2-Dimethyl-6-(4-fluorophenyl)morpholine hydrochloride

생성물 1

HCID 600017962-[2,2-Dimethyl-6-(4-Fluorophenyl)morpholin-4-yl]-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one수율 85.7%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A solution of 2,2-dimethyl-6-(4-fluorophenyl)morpholine hydrochloride (127 mg, 0.517 mmol), 2-chloro-3-methyl-6-(4-pyridyl)-pyrimidine-4-one (109 mg, 0.491 mmol) and triethylamine (0.180 ml, 1.29 mmol) in N,N-dimethylformamide (2 ml) was stirred at room temperature. After stirring for several hours, water was added to the reaction mixture. The precipitate was filtered, washed with water and dried to give the title compound (166 mg, 81%).

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-e0e475faa70b4ac49a3f05319e13d0f4
출처 데이터셋
uspto-grants-2008_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07427615B2

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