3-Fluoro-2-nitrophenol → 2-amino-3-fluorophenol
반응식
[N+:1]([C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:11])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:11]참가 물질
4
실험 절차
To a solution of 2-nitro-3-fluorophenol(1 g, 6.4 mmol) in methanol(250 mL) was added 10% Pd/C (1 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(650 mg, 80.2%). 1H NMR (CD3OD): d 6.41-6.17 (m, 3H).
후처리
- customThe mixture was flushed with argon
- customhydrogen was bubbled through the solution for 10 min.
- temperaturea hydrogen atmosphere was maintained at balloon pressure overnight
- filtrationThe mixture was filtered through celite
- washthe celite was washed with methanol
- customThe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-1da63e5ca93f4d98bbd20fb505483695
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06211373B1
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