Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(4-benzoylpiperidin-1-yl)-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Benzoylpiperidine hydrochloride | HCID 2724437 | — |
| 반응물 | 4(3H)-Pyrimidinone, 2-chloro-3-methyl-6-(4-pyridinyl)- | HCID 11276081 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(4-benzoylpiperidin-1-yl)-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one | HCID 10270762 | 89% |
반응 단계
A solution of 4-benzoylpiperidine hydrochloride (903 mg, 4.00 mmol), 2-chloro-3-methyl-6-(4-pyridyl)-pyrimidine-4-one (666 mg, 3.00 mmol) and triethylamine (2.0 ml, 15 mmol) in tetrahydrofuran (30 ml) was refluxed for several hours. After cooling, water was added to the reaction mixture. The precipitate was filtered, washed with water and dried to give the title compound (1.00 g, 81%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07427615B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-44efc349c3504155aea8a71c078d081c |
| 출처 메모 | uspto-grants-2008_09 |