Piperazine → HCID 22010937, 화합물

HRID 323137노트

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HRID 323137 반응식
[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24]C2C=CC=CC=2)=O)=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.[CH3:40]N(C)C=O>C(OCC)(=O)C>[N+:1]([C:4]1[CH:33]=[CH:32][C:7]([C:8]([N:10]([CH3:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]([N:34]2[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]2)=[O:24])=[O:9])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 6228DimethylformamideHCID 220105644-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide

생성물 1

HCID 22010937HCID 22010937, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
80 °C

실험 절차

A mixture of 4-nitro-N-methyl-N-[2-(3-phenoxycarbonylaminoprop-1-yloxy)phenyl]benzamide (383 mg) and piperazine (256 mg) in N,N-dimethylformamide (8 ml) was stirred at 80° C. for 3 hours. The reaction mixture was diluted with ethyl acetate and then the organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine. Drying, filtering and removal of solvents afforded 4-nitro-N-methyl-N-[2-{3-(4-methyl-1-piperazinyl)carbonylaminoprop-1-yloxy}phenyl]benzamide (357 mg) as a slightly yellow oil.

후처리

  1. washthe organic solution was washed successively with saturated sodium bicarbonate aqueous solution and brine
  2. customDrying
  3. filtrationfiltering
  4. customremoval of solvents

출처 및 근거

ORD 기록
ord-a3d31a6965364de9a8b4ed9347b47f78
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211242B1

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