Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-formylphenyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Magnesium peroxide (Mg(O2)) | HCID 61745 | — |
| 반응물 | 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide | HCID 22010765 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-formylphenyl)benzamide | HCID 22010987 | 93.3% |
반응 단계
A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide (225 mg) and magnesium dioxide (651 mg) in chloroform (10 ml) was refluxed for 3 hours and the solution was filtered through Celite. The filtrate was evaporated in vacuo to give a crude oil and the oil was subjected to silica gel column (1% methanol in chloroform). The product was solidified with diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-formylphenyl)benzamide (209 mg) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211242B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-5a15c12ba5824e078d19a9fdc2ba8f51 |
| 출처 메모 | uspto-grants-2001_04 |