Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine | HCID 13808349 | — |
| 촉매 | Palladium hydrate | HCID 23219155 | — |
| 용매 | Triethylamine methanol | HCID 22728368 | — |
| 생성물 | (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine | HCID 13808350 | — |
반응 단계
Combine (1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)(1-benzylpiperidin-4-yl)amine (0.51 g, 1.35 mmol), 20% palladium hydroxide-on-carbon, and methanol (40 mL). Hydrogenate in a Parr apparatus at an initial pressure of 40 psi. After 24 hours, filter through celite, rinse with methanol, and evaporate in vacuo to obtain a residue. Chromatograph the residue on silica gel eluting with 4% triethylamine/methanol to give the title compound: Rf=0.28 (2% triethylamine/methanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211199B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-43ddb64bf073452cbda6993d69b3f918 |
| 출처 메모 | uspto-grants-2001_04 |