Potassium Hydroxide → (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine

HRID 323340노트

반응식

HRID 323340 반응식
[OH:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[NH:18][CH:19]2[CH2:24][CH2:23][N:22](C(OCC)=O)[CH2:21][CH2:20]2)=[CH:5][CH:4]=1.[OH-].[K+]>C(O)(C)C>[OH:1][CH2:2][C:3]1[O:7][C:6]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 22009043(1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine

생성물 1

HCID 22009201(1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzoimidazole-2-yl)(piperidin-4-yl)amine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

According to the procedure of European Patent Application 0 393 738 A1, hydrolyze (1-(5-hydroxymethylfur-2-ylmethyl)-1H-benzimidazol-2-yl)(1-ethoxycarbonylpiperidin-4-yl)amine using potassium hydroxide in isopropanol to give the title compound.

출처 및 근거

ORD 기록
ord-321583207b30436da2280a060f971f1c
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211199B1

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