Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Hydrogen iodide | HCID 24841 | — |
| 반응물 | (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine | HCID 22009233 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt | HCID 86756597 | — |
반응 단계
Combine (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine, ethylene ketal (0.9 g, 2.0 mmol) and dichloromethane (20 mL). Cool in an ice bath and add hydriodic acid (0.53 mL, 57%, 4.05 mmol). Warm to ambient temperature. After 0.5 hours, add water (0.5 mL) and heat to reflux. After 18 hours, cool to ambient temperature and evaporate in vacuo to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06211199B1 |
| 출처 데이터셋 | uspto-grants-2001_04 |
| ORD ID | ord-70c33d0dc40746d3859726d21fe62f3e |
| 출처 메모 | uspto-grants-2001_04 |