Potassium Hydroxide → 5-Mesyl-o-anisic acid

HRID 323395노트

반응식

HRID 323395 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[K+]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([S:13]([CH3:16])(=[O:15])=[O:14])=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]

참가 물질

3

반응물 2

HCID 14797Potassium HydroxideHCID 6454622Methyl 5-mesyl-o-anisate

생성물 1

HCID 1708405-Mesyl-o-anisic acid

실험 절차

Combine methyl 2-methoxy-5-methylsulfonylbenzoate (2.24 g, 9.2 mmol) and a 1 M aqueous potassium hydroxide solution (10 mL, 10 mmol). Heat to reflux. After 2 hours, filter while still hot, cool in an ice bath, and acidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL) to give a solid. Collect the solid by filtration, rinse with water, and dry to give the title compound.

후처리

  1. temperatureHeat to reflux
  2. filtrationfilter while still hot,
  3. temperaturecool in an ice bath
  4. additionacidify by dropwise addition of a 1 M aqueous hydrochloric acid solution (11 mL)
  5. customto give a solid
  6. customCollect the solid
  7. filtrationby filtration
  8. washrinse with water
  9. customdry

출처 및 근거

ORD 기록
ord-51e6a8f6e2ec4f5b836d67b9f2ad5d02
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211199B1

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